Pediatric Ferrous Sulphate Solution

SOLUTIONS

Pharmaceutical solutions may be generally defined as liquid preparations in which the therapeutic agent and the various excipients are dissolved in the chosen solvent system. Pharmaceutical solutions may contain a range of excipients, each with a defined pharmaceutical purpose.

Excipients includes -

  1.  Vehicle, usually purified water 
  2. Co-solvents, e.g. propylene glycol, glycerin, alcohol 
  3. Agents specifically to enhance the solubility of the therapeutic agent in the vehicle, e.g. surface-active agents 
  4. Preservatives salts, sorbic acid and sorbate salts, phenolics
  5. Sweeteners, e.g. glucose, saccharin, aspartame 
  6. Rheology (viscosity) modifiers, e.g. hydrophilic polymers (cellulose derivatives, alginic acid, polyvinylpyrrolidone) 
  7. Antioxidants
  8. Colours
  9. Flavours
  10. Buffers to regulate the pH of the formulation, e.g. citrate buffer

STRUCTURE

Molecular weight - 151.908 g/mol


THEORY

Ferrous sulfate is a synthetic agent used in the treatment of iron deficiency. It is the gold standard of oral iron therapy in the UK and many other countries.

It is an OTC product.

The solution contains ferrous sulphate serving as the source of iron. 

Ascorbic acid acts as an antioxidant thereby prevent the oxidation of ferrous sulphate to ferric sulphate. 

Orange syrup as a flavouring agent. 

Chloroform water is used as a preservative. 

Purified water as vehicle



FORMULA



Time to put on your lab coat ! 

PROCEDURE

  1. Ascorbic acid was dissolved in chloroform water. 
  2. Weighted quantity of ferrous sulphate was dissolved in above solution
  3. Orange syrup was added
  4. The solution was filtered through a filter paper and the volume was made up by passing purified water through the filter

Direction of use - one teaspoon full to be given twice a day with plenty of water. 

Shelf life - 2 weeks






Brand names: FeroSul, Slow Fe, Feosol Original

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